Influence of the antigenicity of Brucella preparations on modulation of the immune response to sheep erythrocytes.

B and T-Cell Epitope Prediction of the OMP25 Antigen for Developing Brucella melitensis Vaccines for Sheep

Brucellosis, produced by Brucella species, is a disease that causes severe economic losses for livestock farms worldwide Due to serious economic and medical consequences of this disease, many efforts have been made to prevent the infection through the use of recombinant vaccines based on Brucella outer membrane protein (OMP) antigens. In the present study, a wide range of on-line prediction sof...

Design and Production of a Novel Recombinant Chimeric IL2-Omp31 Antigen against Brucella Infection

Brucellosis is a zoonotic disease in human and animals. Brucella melitensis is one of the most pathogenic species of Brucella in goat and sheep. Omp31 is an outer membrane protein of Brucella that acts as an immunogenic protein. Cytokines are glycoproteins with low molecular weight that play the role of an immune adjuvant and regulate immune responses. Interleukin-2 is one of the most important...

Growth performance and immune response of broiler chickens fed diets supplemented with probiotic and (or) prebiotic preparations

The objective of this research was to investigate the efficacy of dietary inclusion of probiotics Primalac® and Bactocell® and prebiotic Fermacto® on broiler’s performance and immune response, individually or in combination. A total of 540 one-d-old male Ross 308 broiler chicks were allocated into 6 experimental treatments with 6 replicates of 15 birds per replicate from 1 to 42 d of age. The b...

Comparison of various serological tests on the milk of sheep in relation to the isolation of Brucella melitensis

Brucella abortus L7/L12 Recombinant Protein Induces Strong Th1 Response in Acute Brucellosis Patients

Background: Because of high morbidity of the brucellosis in humans and the potential use of the microorganism as an agent of biologic warfare, protection of effective vaccines and specific diagnostic reagents become necessary to eradicate brucellosis. Objective: In this study we aimed to investigate the cytokine responses and changes in peripheral blood lymphocyte subgroups of acute brucellosis...